TEACHING LEARNING MATERIAL
BLOOD GROUPING TLM
There are 4 main blood groups defined by the ABO system:
- blood group A – has A antigens on the red blood cells with anti-B antibodies in the plasma
- blood group B – has B antigens with anti-A antibodies in the plasma
- blood group O – has no antigens, but both anti-A and anti-B antibodies in the plasma
- blood group AB – has both A and B antigens, but no antibodies
Blood group O is the most common blood group. Almost half of the UK population (48%) has blood group O.
Receiving blood from the wrong ABO group can be life-threatening. For example, if someone with group B blood is given group A blood, their anti-A antibodies will attack the group A cells.
This is why group A blood must never be given to someone who has group B blood and vice versa.
As group O red blood cells do not have any A or B antigens, it can safely be given to any other group.



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